| ncRNA name | BDNF-AS |
| ncRNA Category | lncRNA |
| ID | 78998 |
| Ensembl | ENSG00000245573 |
| Synonyms | BDNF-AS1, BDNFAS, BDNFOS, BT2A, BT2B, BT2C, BT2D, NCRNA00049 |
| Disease name | retinoblastoma (RB) |
| Species | Homo sapiens |
| Tissues/Cell_line | RB samples; RPE cell line ARPE-19; human telomerase-immortalized RPE cell line hTERT-RPE1; RB cell line Y79, WERIRb-1, Rb116, Rb143, SO-RB50 and HXO-RB44 |
| Methods | qRT-PCR, transfection, viability assay, MTT assay, transwell assay, cell cycle assay, Western blot |
| Expression pattern | down-regulated |
| Functional description | Low BDNF-AS expression is associated with shorter overall survival and may be acting as an independent marker in RB. In Y79 and WERI-Rb-1 cells, forced overexpression of BDNF-AS inhibited cancer proliferation and migration. It also induced cell-cycle arrest at G0/G1 phase by downregulating CDC42, Cyclin E and BDNF. |
| PubMed ID | 28131827 |
| Year | 2017 |
| Title | Long noncoding RNA BDNF-AS is a potential biomarker and regulates cancer development in human retinoblastoma. |
| Drug-related ncRNA | NO |
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